Unit Code: PHM710

Unit Name: Pharmaceutics(Pharmacokinetics)

Description: This course is designed to provide students with knowledge on how the body handles the drugs once administered into the body. The strategy for optimum treatment of patients with drugs is to give sufficient amounts for the required therapeutic effect to arise, but not the toxic effect. Pharmacokinetics is a branch of Therapeutics that includes; the study of mechanisms of absorption and distribution of an administered drug, the rate at which a drug action begins and the duration of the effect, the chemical changes of the drug in the body (metabolism by enzymes) and the effects and routes of excretion of the metabolites of the drug or intact drug. It examines the relationships among dose, plasma concentration and the subsequent therapeutic or toxic effect. The application of Pharmacokinetic concepts to clinical practice enables safe and effective therapeutic management of individual patients.

Learning Target Outcomes: On successful completion of this course, the students will be able to: 1. Define Pharmacokinetics. 2. Create plasma drug concentration versus time curves. 3. Discuss principles of drug absorption, distribution, metabolism and excretion. 4. Discuss principles of the One Compartment model. 5. Discuss principles of Bioavailability and Bioequivalence. 6. Discuss modified release of drug products. 7. Differentiate between linear and non-linear pharmacokinetics. 8. Design therapeutic regimens for specific patient groups using appropriate formulas in an ethical manner. 9. Perform therapeutic drug monitoring. 10. Discuss the relationship between pharmacokinetics and pharmacodynamics. 11. Compound extemporaneous preparations as per laboratory manual.

Prerequisite: PTH610, PHM610, PHM612, PHM611 & PHM613

Prerequisite Sentence: N/A

Credit Point: 30

Offered In: Semester 1,2